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Fatigue and headaches usually resolve within two to four weeks as your body adapts

Practical steps to minimize this concern: Take levothyroxine immediately upon waking, before any food or other medications Wait at least 60 minutes (rather than the minimum 30) before eating, to allow more absorption time Consider splitting the levothyroxine dose if absorption seems compromised (discuss with your endocrinologist) If oral absorption becomes problematic, liquid levothyroxine or gel capsule formulations may offer more reliable absorption Dosing Requirements Levothyroxine dose is roughly 1.6 mcg/kg of ideal body weight

Slower titration or drug holidays help persistent cases

If you are choosing between formats, that distinction matters