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Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption

Adverse Reactions/Side Effects In most cases, methylcobalamin is nontoxic, even in large doses

Food intake remained consistent between the groups, suggesting metabolic changes

For researchers interested in body recomposition rather than just weight loss, these properties are particularly valuable