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Variability of DNA methylation within schizophrenia risk loci across subregions of human hippocampus
Published studies using Horvath-clock and DNAm GrimAge epigenetic aging measurements have found that MTHFR C677T T/T status is associated with accelerated epigenetic aging biological age running ahead of chronological age with effect sizes that are modest at adequate folate intake but become more pronounced under folate insufficiency
This is misleading because true adrenal insufficiency (Addisons disease) is a rare, medically recognized condition where the adrenal glands cannot produce enough hormones due to an underlying disease, which is not the case in so-called adrenal fatigue
Fischer, T
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