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Developing tirzepatide required years of large-scale clinical trials, including the SURMOUNT trial program, which ran across thousands of participants over multiple years before FDA approval was granted
Altered glucose metabolism in microvessels from patients with Alzheimer's disease Ann Neurol 1989
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No large randomized controlled trial directly compares monotherapy against the combination, and what exists is limited observational data and small case series suggesting an additive effect
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