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Trulicity starting dose is 0.75 mg once weekly for the first month, which can be increased to 1.5 mg in the second month, and further increased in 1.5 mg increments up to a maximum dose of 4.5 mg weekly based on therapeutic response

This interaction was suggested to induce bowel movement, though the potential connection between specific peptides and bowel release are still under investigation

In clinical trials (e.g., SURMOUNT-1), tirzepatide led to significant weight loss, an average weight loss of 15%20% of body weight over 72 weeks, when combined with diet and exercise

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