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160,161,162 MCU stimulates PDAC cell invasion, migration, and metastasis via activating the Kelch-like ECH-associated protein 1 (Keap1)-Nrf2 antioxidant pathway
This makes the arginate version significantly more stable in liquid and across various pH levels, especially in the acidic environment of the stomach
Furthermore, PMP displayed dose-dependent activity (MIC = 0.1 mg/mL, MBC = 10 mg/mL), achieving inhibition rates of 72.6% (100 mg/mL), 69.9% (10 mg/mL), and 50.5% (1 mg/mL)
It is essential for DNA synthesis and contributes to overall energy metabolism
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