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The extracellular L-cysteine/L-cystine redox balance, and thus the synthesis of GSH, is finely regulated by the intracellular conversion of L-cystine into L-cysteine (10), and its impairment is related to oxidative stress and other pathological disorders

Genetic variants can impact how well you produce glutathione and detoxify certain toxicants

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Activators of GPXs To our knowledge, most literature studies on enhancing GPXs activity were about how to regulate expression of GPXs, study on the activator by acting the enzyme directly was few and most of them are GPXmimetic compounds