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During follow-up, the patient described paresthesia on the left side and noted similar sensations extending to his right thumb
Once-weekly dosing therefore produces sustained drug concentrations that are an order of magnitude or more above physiologic baseline
Ferdinand KC, Botros FT, Atisso CM, Sager PT
The jump from 1 mg to 2 mg adds only 0.3 percentage points of additional HbA1c reduction but doubles the nausea rate
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