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Activation of DRs initiates second messengers, which trigger or block the activation of specific cell signaling pathways in post-synaptic neurons [27]

In addition, amino acids have a profound influence on the fate of immune and tumor cells in the TME

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As IGF-1R mAbs are already in clinical trials, these observations warrant further exploration into the possible development of these drugs for safe and effective long-term use in humans as a strategy to delay at least some manifestations of aging