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A 2020 preclinical safety evaluation (Xu et al., 2020, Regul Toxicol Pharmacol ) confirmed a favorable profile at research-relevant doses with no significant organ toxicity at tested concentrations

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Newer antidepressants are often good alternatives that are much safer than benzodiazepine

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In the absence of other signs and symptoms of acute pancreatitis, elevations in pancreatic enzymes alone are not predictive of acute pancreatitis

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