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In this model, mice undergoing testicular torsion showed enhanced levels of oxidation (i.e., malondialdehyde, 3-nitrotyrosine), inflammatory [i.e., hypoxia-inducible factor-1, tumor necrosis factor- (TNF-), etc .], and proapoptotic markers (i.e., caspase3, etc .) in association with downregulation of KISS-1 and its receptor (KISS-1R) in testis [142]
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