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The strongest, clearest evidence is biochemical: growth hormone releasing compounds like CJC-1295 raise growth hormone and IGF-1, and studies of growth hormone secretagogues confirm they can increase IGF-1, a measurable marker on the pathway (a 2017 study showing a growth hormone secretagogue raised serum IGF-1)
For in vitro samples both the media and lysate were normalized to the lysate protein
One is a GHRH and one is a GHRP
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