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Because studies done on it so far for typical depression arent high-quality, "its fine to try it as an adjunct to other treatments, but do it under your doctors guidance," says Viswanathan

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Practically, any before & after changes attributed to MIC/B12 should be viewed as adjunctive to fundamentalscalorie deficit, adequate protein, resistance training, daily steps, and sleeprather than a guaranteed pharmacologic effect

FOXO4-DRI theoretically has higher selectivity by targeting the FOXO4-p53 interaction that is specifically elevated in senescent cells