natural glp-1 hormone Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response Questions about GLP-1s? A Providence

Mice exposed to chronic unpredictable mild stress (CUMS) for 6 weeks showed increased hypothalamic corticotropin-releasing hormone concentrations, elevated corticosterone levels and increased blood ammonia, which corresponded with anxiety-like behaviors, demonstrating HPA axis involvement in anxiety pathogenesis (Jia et al., 2024)

Semaglutide drug monograph, BNF

For many gastrointestinal conditions, probiotic benefits typically emerge after 48 weeks of continuous use, though evidence specifically for metabolic outcomes remains limited

Its important to understand this risk so you can take steps to stay nourished and healthy while using a GLP-1 RA