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doi: 10.1071/RD17507 8 KirillovaASmitzJEJSukhikhGTMazuninI

10.1371/journal.pone.0146654 92 RodriguezD.KapoorS.EdenhoferI.SegererS.RiwantoM.KiparA.et al (2015)

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However, a drawback of these medicines has been the necessity for administration by subcutaneous injection, which limits patient utilization and may reduce opportunities for fixed-dose combination treatments with other small-molecule drugs