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Aging Cell 2013

reduced GABA signaling is linked to heightened anxiety Serotonin and dopamine influence mood regulation and motivation Glutamate drives excitatory signaling that, in excess, can fuel overactive stress circuits Chronic stress can also trigger low-grade neuroinflammation, a process increasingly tied to both anxiety and depression in clinical studies

94 Although the mechanistic basis remains less well defined than in the kidney, these findings suggest that highly organized tissue architecture may impose directional constraints on ferroptotic spread, effectively channeling the trajectory of injury through anatomical structure