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Ultimately, follow-on assets that are most successful will possess some combination of convenient dosing, demonstrated benefits on the liver/heart/kidney, and improved GI tolerability
Fornes, A., Huff, J., Pritchard, R
It is likely that controlling for these variables will offer a clearer picture of the trait vs state role of GSH, and in future pharmacological studies may additionally help in this regard
The anti-PCSK9 antibody Ab#2 was affinity matured by rational design using a structure homology model of the mAb in complex with human PCSK9 to generate the optimised version Ab#2.1, which should deliver robust PCSK9 suppression at lower doses than Ab#2
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