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If phase 3 results remain positive, regulatory submissions may begin in 2026, meaning orforglipron could become available in late 2026 or 2027, depending on MHRA and NICE approval timelines
GLP-1R has been detected in the substantia nigra (Merchenthaler et al., 1999), its role in food reward behavior is unexplored, but is certainly worth considering in future studies
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