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Physical activity stimulates peristalsis through mechanical vibration, increased blood flow to the gut, and activation of the parasympathetic nervous system

It is also unclear if specific incretin receptor agonists, for example selective GIP receptor and GLP-1 receptor agonists will possess different efficacies across tissue types

Based on this NMA, with the exception of an increased incidence of hypoglycemia in the Exenatide 2.0 mg group compared with placebo, other GLP-1RAs had lower incidences of both hypoglycemia and gastrointestinal reactions than placebo