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26,27 Some studies have shown that the intestinal SMCs are capable of producing several cytokines such as IL-6 and TNF- under different pathological conditions

But the most important shift may not be pharmacological

TNF- (tumor necrosis factor alpha) and IL-6 (interleukin-6) expression decrease substantially through NF-B pathway suppression, while 127 genes in COPD patients shift from tissue destruction to repair patterns after GHK-Cu treatment

10-13 In subsequent trials where higher doses of the GLP-1/GIP agonists were used in non-diabetic obese subjects, weight loss of 15% to 21% of body weight was seen