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In bronchial epithelial cells, renal epithelial cells, and neurons, ALOX15 binds to phosphatidylethanolamine-binding protein 1 (PEBP1) and triggers RSL3-induced ferroptosis (65)
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That includes synthetic peptides, which mimic their naturally occurring counterparts in form and function
For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145
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