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Additionally, low-dose berberine protected PC12 cells from 6-hydroxydopamine (6-OHDA, Parkinsons disease-related neurotoxin)-induced cytotoxicity and apoptosis, whereas high-dose berberine showed no neuroprotective activity

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Relative to the interface of oxidative stress with the formaldehyde detoxification pathway, glutathione, a main substrate for the antioxidant activity of glutathione reductase in the oxidative pathway [10] [14] , binds with formaldehyde, which is the first step in clearing of formaldehyde [15]