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At baseline, trained nurse interviewers administered a structured questionnaire to each subject to collect comprehensive information on demographics, occupation, lifestyle habits, medical history, usage of medication and dietary supplements, alcohol consumption, and past cigarette smoking history
After intracerebral hemorrhage, the HDAC1/2 inhibitor Lomidesine (FK228) can alter microglial heterogenization, reduce neuroinflammation, and alleviate neuronal ferroptosis, possibly through regulating the Nrf2/HO-1 signaling pathway
The composition and function of the microbiota are susceptible to environmental factors, such as diet and antibiotics, acting as critical mediators of host defense strategies 36
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