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Unlike other GH secretagogues, ipamorelin very surprisingly does not induce a significant increase in adrenocorticotropic hormone (ACTH) or cortisol levels

In rodent models, Sema has been shown to activate GLP-1 receptors in the hypothalamus, indirectly affecting TSH (thyroid-stimulating hormone) levels and downstream thyroid hormone regulation

The results showed a 20% reduction in the risk of a composite of cardiovascular death, nonfatal myocardial infarction (MI) or nonfatal stroke relative to placebo over approximately 40 months of follow-up

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