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Since then, amyloid and tau proteins have been sought in numerous biological media, including CSF, blood, urine, saliva, and skin, with varying degrees of success

While the H 2 FPEF scoring system defines the most clinically relevant features that HFpEF animal models should manifest, whether these comorbidities are mechanistically relevant to HFpEF pathogenesis remains unclear

These approaches can aid in the identification of predictive biomarkers and therapeutic targets, ultimately enhancing the precision and effectiveness of treatment

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