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See also: Silymarin (Milk Thistle) for Dogs and Cats How it is given SAMe is usually: given once daily provided as tablets or capsules Important points: best given on an empty stomach for absorption many products are enteric-coated to protect the compound Consistency matters for effectiveness

The decline is gradual rather than sudden, which researchers note is consistent with a compound that functions as an ongoing signaling factor in tissue maintenance rather than one tied to a single life stage or event

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