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The best candidates will satisfy both conditions: they will report a pathway such as FAO bottleneck, BCAA catabolic defect, NAD + depletion, redox stress, or ketone adaptation, and they will improve prediction or treatment response beyond standard variables

The non-management of chronic pain in the elderly can have large repercussions in terms of health and well-being with a high risk of depression, altered physical activity, higher outcomes of falls and malnutrition, and so an altered quality of life ( Reference Perrot 74 , Reference Ayres, Warmington and Reid 84 )

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