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PMID 21577242
The knockout of ATM can also lead to an increase in H 2 O 2 within HSCs and induce excessive proliferation and differentiation of HSCs through the activation of the p38-MAPK pathway, ultimately leading to HSC exhaustion [294]
In a phase 2 study in people with obesity (without T2D), retatrutide (doses 1 to 12 mg) has led to a dose-dependent WL up to 24.2% at the end of the 48-week treatment period compared to 2.1% with placebo [81]
While this additive effect might seem beneficial, unmonitored combination therapy can lead to dangerously low blood glucose levels
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