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Long-acting agents seem to have a lower incidence of gastrointestinal adverse effects (166), likely due to tachyphylaxis in gastric emptying with sustained GLP-1R stimulation
Clinically, elevated levels of endogenous GLP-1 have been observed in patients with sepsis (6.35-fold increase), end-stage renal disease (4.46-fold), and burns (2.96-fold), indicating a common physiological response to critical illness (Lebherz et al., 2017)
10.1111/j.1464-410x.2005.05472.x 3 ChangM.HouZ.WangM.LiC.Al KheraifA
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