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Moreover, in isolated rat cardiac MVECs treated with Ang II (4 nM) during 48 h, an induction of apoptosis was observed via regulation of the protein tyrosine phosphatase 1B/PI3K/Akt pathway [96]

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Collectively, this could point to highly immunogenic tumor profiles in GAN DIO-NASH-HCC mice which could potentially be indirectly or directly targeted by drugs in late-stage development for NASH

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