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This phenomenon occurs through several metabolic mechanisms: Increased breakdown of purines : When the body metabolises fat and muscle tissue during weight loss, purines (compounds found in body tissues) are broken down, producing uric acid as a by-product Ketone body production : Rapid weight loss, particularly with very low-calorie diets, leads to ketone production, which competes with uric acid for excretion by the kidneys Reduced renal clearance : Ketones and other metabolic by-products can temporarily impair the kidneys' ability to excrete uric acid efficiently Dehydration : Weight loss programmes may involve reduced fluid intake or increased fluid loss, concentrating uric acid in the blood The rate of weight loss appears to be a critical factor
Can GLP-1s be used during pregnancy
It is consistent, predictable, and reassuring once you know what causes it
This cardiovascular protective effect is something other GLP-1 medications have not yet demonstrated at the same level, making Wegovy widely regarded by clinicians as the current gold-standard option specifically for obesity with cardiovascular risk
