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This prolonged retention increases pressure, fullness, and discomfort, especially after larger, protein-dense, or high-fat meals, even though digestion continues normally and food is not physically blocked. Large meal volume and gastric distension Larger meal volumes cause the stomach to stretch

Stopping before 12 months significantly increases the likelihood of weight regain without having built the foundation to prevent it

The list also includes Vertex Pharmaceuticals combination therapy for cystic fibrosis, Trikafta or Kaftrio

Do not use if you are pregnant, planning to become pregnant, or breastfeeding, because safety data are limited