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A significant reduction in appetite and food intake was also observed with tirzepatide compared to placebo in people with T2D [45]

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With respect to their individual use, important questions remain unanswered, including whether or not GLP-1RA reduces the risk of end stage kidney disease or doubling of serum creatinine in cohorts with DKD at baseline - a question currently being studied in the ongoing FLOW trial with semaglutide