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Mounting evidence from humans and animal models supports an important role for accumulated metabolites, particularly leucine and -KIC, in the pathogenesis of brain injury in MSUD [75]

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B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial. The Journal of Prevention of Alzheimers Disease, vol