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Red flag symptoms that necessitate urgent medical review include: Symptoms of severe hypoglycaemia : confusion, difficulty speaking, loss of consciousness, seizures, or inability to self-treat low blood sugar Signs of dehydration : reduced urine output, dark-coloured urine, extreme thirst, dry mouth, sunken eyes, or rapid heartbeat Cardiovascular symptoms : chest pain, palpitations, irregular heartbeat, or shortness of breath accompanying dizziness Neurological symptoms : severe headache, visual disturbances, slurred speech, weakness, or numbness, which may indicate more serious conditions requiring immediate investigation Syncope or near-syncope : actual loss of consciousness or feeling as though one is about to faint Call 999 or go to A&E immediately if experiencing symptoms suggestive of stroke (facial weakness, arm weakness, speech problems), severe chest pain, or loss of consciousness

AAPE treatment significantly stimulated stress fiber formation, which was linked to the RhoA-ROCK pathway