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E., Roth, D

No significant differences in nerve conduction study data and in the incidence of adverse events between the two groups of patients were observed

The greatest changes in NCV (at 12 months) were observed in the sensory sural nerve (+5.7 m/sec in the LAC group vs +1.0 m/sec in the placebo group), sensory ulnar nerve (+2.9 vs +0.1 m/sec, respectively) and motor peroneal nerve (+2.7 vs 0.2 m/sec), whereas the greatest changes in amplitude were recorded in the motor peroneal nerve (+2.2 vs +0.1 mV)

This shift appears driven more by market demand and GI tolerability concerns than by any negative research findings about levocarnitine itself