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NICE guideline NG28 recommends GLP-1 receptor agonists for adults with type 2 diabetes who have a BMI of 35 kg/m or higher (adjusted for ethnicity) and specific psychological or medical problems associated with obesity, or a BMI lower than 35 kg/m where insulin therapy would have significant occupational implications or weight loss would benefit other significant obesity-related comorbidities

Ann Pharmacother 2010