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However, skeletal muscle-specific carnitine palmitoyltransferase 2 (CPT2)-deficient mice accumulate large amounts of acylcarnitine in muscle and plasma and still preserve insulin sensitivity [75], highlighting the role of acylcarnitine only as an indicator of FAO rather than as a direct mediator of insulin resistance [76]

These bone biology studies established Ipamorelin as the reference GH secretagogue for studying GH-specific skeletal anabolic biology and demonstrated the research value of selectivity in contexts where cortisols bone catabolic biology would otherwise obscure GH-specific effects

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