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Description

Ozer, M

Selective NNMT inhibitors (including 5-Amino-1MQ) lower 1-MNA, increase NAD and SAM, suppress adipocyte lipogenesis, and reverse HFD-induced obesity in mice [1]

Developing adaptive techniques and strategies to get around apparent disabilities (e.g., keyboarding or using a weighted pencil to facilitate handwriting)

Although measuring adaptive behavior was not a primary outcome of that trial, the improvements in this assessment gained the FDA's breakthrough therapy label (56)