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Tseng P-T, Chen Y-W, Stubbs B, Carvalho AF, Whiteley P, Tang C-H, et al

This is in contrast to the situation in pigs (24) and in dogs (15), where total GLP-1 levels, estimated using a COOH-terminally directed RIA, are underestimated by 50% due to cleavage by NEP 24.11, as revealed in pigs using a NEP 24.11 inhibitor (24)

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Conclusion Our results suggest that prolonged administration of MK-677 in rats does not promote growth despite the GH stimulatory effect of MK-677, which may be related to increased expression of SST in the hypothalamus