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Abbreviations ACTH: Adrenocorticotrophin hormone -MSH: -Melanocyte stimulating hormone BBB: Blood-brain barrier -END: Beta-endorphin -end / : Genetic notation for mutation that expresses all melanocortin peptides except -endorphin -LPH: Beta-lipotropin -MSH: Beta-melanocyte stimulating hormone cAMP: Adenosine 3,5-monophosphate C57BL/6J: Species of mouse (wild type) CLIP: Corticotrophin-like intermediate lobe peptide CNS: Central nervous system COMT : Gene encoding catechol-O-methyltransferase) CYP2D6: Cytochrome P450 2D6 metabolic enzyme -LPH: gamma-lipotropin GCH1 : Gene encoding GTP (guanosine triphosphate) cyclohydrolase 1 GTP: Guanosine triphosphate HLA: Human leukocyte antigen K14-SCF: Notation for mice with increased epidermal melanocytes MAC: Minimum alveolar concentration MC1R: Melanocortin 1 receptor Mc1r : Alleles for MC1R Mc1r : e/e Mutant mice lacking MC1R MC3R: Melanocortin 3 receptor MC4R: Melanocortin 4 receptors Mc4r : Allele for MC4R Mitf mi wh/mi : wh Allele notation for mice lacking melanocytes [Nle4,D-Phe7]--MSH: Melanocortin agonist N-POC: N-pro-opiomelanocortin OPRM1: -Opioid receptor for -endorphin Oprm1 : / Genetic notation for a strain lacking -opioid receptor for -endorphin PC: Proconvertase POMC: Proopiomelanocortin QTL: Quantitative trait locus SHU-9119: Melanocortin receptor antagonist Tyr : c/c Genetic notation for albino mice U50,488: Broad -opioid agonist UV: Ultra-violet WT: Wild type References Liem EB, Lin C, Suleman M, Doufas AG, Gregg RG, Veauthier JM, et al