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Risperidone When administered concomitantly with topiramate at escalating doses of 100, 250, and 400 mg/day, there was a reduction in risperidone systemic exposure (16% and 33% for steady-state AUC at the 250 and 400 mg/day doses of topiramate)

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doi: 10.1111/j.1365-2125.2012.04214.x 106 SmitsMMTonneijckLMuskietMHAHoekstraTKramerMHHDiamantMet al