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GLP-1 receptor-mediated effects are the most well-characterised and include: Nausea, vomiting, and diarrhoea typically dose-dependent and most prominent during dose escalation Reduced appetite and early satiety Pancreatitis has been reported with GLP-1 receptor agonist class medicines

They both cause vomit and diarrhea

This controlled absorption profile is fundamental to tirzepatide's once-weekly dosing schedule and its favorable efficacy and tolerability profile

The underlying absorption challenges are nearly identical for both peptides, so switching between sublingual formulations rarely solves the core problem