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Experience with oral GLP1 use in diabetes has highlighted this disconnect: tablets are often not viewed as premium products, and the scientific and manufacturing innovation required to enable the oral delivery of biologics can be underappreciated at times reduced to just a pill. This perception gap may pose commercial challenges, especially when oral therapies are priced alongside injectable alternatives
Eight RCTs (assessed with RoB2) had a low risk of bias across all domains, particularly in areas of outcome data completeness, and selective reporting
Important safety considerations include caution in patients with diabetic retinopathy, particularly with semaglutide, as rapid improvement in glucose control may temporarily worsen retinopathy
They just get better each iteration with less side effects, longer half life
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