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Remarkably, in our GLP-1RFab7F38 structure, since no peptide ligand is bound to the orthosteric pocket, the peptide-binding groove of the ECD is juxtaposed with the TMD interacting with ECL1 and ECL3

The FDA approved Zepbound (tirzepatide) in December 2024 for moderate to severe OSA in adults with obesity , used alongside diet + physical activity

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