Overall, GLP-1 medications appear to be safe in older adults, and the rate of serious side effects is similar to what we see in younger people
However, in special situations with exposure to a massive amount of GLP-1 receptor agonists, such as in GLP-1 analog treatment or post-gastric bypass surgery, the tissue level of GLP-1 or its analog is important for determining pancreatic -cell function
In patients with overweight or obesity (mean age 50.1 years, 72.6% female), semaglutide compared with non-GLP1R agonist anti-obesity medications was associated with lower risk for incident (HR = 0.27, 95% CI = 0.200.320.600.36) and recurrent (HR = 0.44, 95% CI = 0.320.60) suicidal ideation, consistent across sex, age and ethnicity stratification
10.1016/j.lfs.2021.120058 34 De BosscherR.DausinC.ClausP.BogaertJ.DymarkowskiS.GoetschalckxK.et al (2023)