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What Semaglutide Is (GLP-1 Receptor Agonist Explained) Semaglutide is a synthetic version of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1)

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Due to a short plasma half-life of native GLP-1, several synthesized GLP-1 receptor agonists (RAs) were developed for type 2 diabetes mellitus (DM) treatment

Last reviewed: July 8, 2026 Last updated: July 8, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations