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Pharmacokinetics of tirzepatide demonstrated dose proportionality over the wide dose range, with C max of 180 nM in individuals treated with one dose of 8 mg and a C max of 260 nM with 15 mg/week dose in the clinical study, exceeding the EC50 values for GIPR and GLP-1R activations by approximately 10,000-fold and 250-fold, respectively (63)
However, individuals with a personal history of medullary thyroid carcinoma or MEN2 should avoid these medications, and those with a family history should consult with a specialist before proceeding
Available online at: (accessed on 08 January, 2025)
