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In a rodent model, a novel GLP-1R/GIPR/GCGR triple agonist, SAR441255, has been shown to promote weight loss and the maintenance of healthy blood glucose levels and is superior to the GLP-1R/GCGR dual agonist (Bossart et al., 2022)

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This epigenetic regulation leads to the suppression of lipogenesis in the liver (Table 1 demonstrates that imbalances in the gut microbiome can lead to various health issues within the gastrointestinal tract