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Defective GABAergic neurotransmission also confers a growth advantage in GBM

The process of detoxification proceeds in three parts or phases, Phase I, Phase II, and Phase lll

The aforementioned pathological changes during the ischemic and reperfusion phasesincluding calcium overload, mitochondrial dysfunction, oxidative stress surge, inflammatory cascade activation, cell death network formation, and microcirculatory dysfunctionare systematically visualized in the schematic diagram, which clearly depicts e sequential progression and interconnections of these mechanisms (Figs